FIG. 1.
Survival curves and viral titers in the hearts of mice infected with EMCV. (A) Wild-type (wt), p50 −/−, IFNRI −/−, and double-knockout (p50 −/− IFNRI −/−) mice, 4 to 6 weeks old, were challenged with an i.p. injection of 103 PFU of EMCV. Survival was monitored at daily intervals. Ten mice were infected in each group. (B) Viral titers in the hearts of mice at day 2 after infection with EMCV. Viral titers were determined as detailed in Materials and Methods. Titers are expressed as PFU per milligram of cardiac tissue. Data points from each heart are shown.