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Percentage urinary excretion of bisphosphonates collected 24 h after i.v. injection (multiple compounds were administered in the same injection) (adapted from ref. [108]). Higher affinity compounds have a lower recovery in the urine. AF647-RIS (compound 52a6 in Fig. 17) & FAM-RIS (compound 52a1 in Fig. 17) are fluorescently labeled bisphosphonates [109,110].
