Fig. 14.

Correlation model of experimental D₂₀ and predicted D₂₀ (predicted D₂₀ (pD₂₀) is calculated from both in vitro FDPS inhibition and bone affinity data, via formula log(pD₂₀) = −0.801 + 1.2605 * log (FDPS IC50 (nM)) − 0.0656 * Affinity − 0.01841 * log(FDPS IC50 (nM)) * Affinity). This model allows a very accurate estimate of the anti-resorptive in vivo efficacy (experimental D₂₀), enabling rapid screening of new analogs based on in vitro data. Each dot represents a bisphosphonate analog, and all clinically used bisphosphonates are annotated in red: PAM – pamidronate (3), NER – neridronate (4), RIS – risedronate (5), ZOL – zoledronate (6), MIN – minodronate (7), ALN – alendronate (8), IBN – ibandronate (9).

(Figure adapted from ref. [108]).