TABLE 3.

Summary of PIT pharmacokinetic changes in male and female OATP1B mice administered vehicle or silymarin after being fed a SC or HFHF diet for 16 weeks

		Pitavastatin
		Vehicle		Silymarin
		SC	HFHF	SC	HFHF
AUC0-12h	All	1.94 (1.71-2.21)	2.68 (2.28-3.16)	2.45 (2.09-2.86)	2.90 (2.34-3.61) **
(µM x h)	Male	1.83 (1.40-2.41)	2.25 (1.73-2.93)	2.00 (1.63-2.45)	2.18 (1.69-2.82)
	Female	2.06 (1.86-2.29)	3.20 (2.70-3.81)	3.00 (2.54-3.54) $	3.87 (3.00-4.98) $$$
Cmax	All	857 (500)	750 (237)	1589 (765)	1240 (1206)
(nM)	Male	732 (689)	708 (260)	992 (458)	749 (302)
	Female	983 (190)	793 (228)	2187 (469)	1731 (1591)
tmax	All	0.38 (0.25-1)	0.5 (0.08-2)	0.5 (0.25-0.5)	0.38 (0.08-2)
(h)	Male	0.5 (0.25-0.5)	1.25 (0.08-2)	0.5 (0.25-0.5)	0.38 (0.08-0.5)
	Female	0.25 (0.25-1)	0.38 (0.25-2)	0.5 (0.25-0.5)	0.38 (0.25-2)
t1/2	All	3.5 (2.2)	2.7 (1.3)	3.2 (1.3)	2.5 (0.8)
(h)	Male	4.2 (2.5)	2.1 (0.6)	3.2 (1.3)	2.3 (0.9)
	Female	2.7 (1.8)	3.3 (1.5)	3.2 (1.4)	2.7 (0.7)

* represent comparisons to SC + vehicle group in all sexes and $ represents comparison with SC + vehicle group of the same sex. A single, double, or triple symbol (*, $) indicates a P value of ≤ 0.05, 0.01, or 0.001, respectively. AUC represents geometric mean (upper and lower 90% confidence interval). C_max and t_1/2 represent arithmetic mean (SD), and t_max represents median (range).