Figure 1.

Quantile-quantile plots of p values showing the association between smoking status and DNAm by tissue type

Results are shown for genome-wide analyses in each tissue (black circles), for the 6,350 CpG associated with smoking based on GTEx lung samples (blue circles), and for the 3,722 CpGs associated with smoking based on prior studies of DNAm in blood samples³⁹ (red circles), adipose samples (orange circles),¹³ and placenta samples (gray circles).¹⁷ Several noteworthy genes with previously reported associations between smoking and DNAm are labeled including AHRR, NOTCH1, and EDC3.