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. 2024 Apr 3;628(8008):639–647. doi: 10.1038/s41586-024-07259-6

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 9 — a, Percentages of prime editing outcomes at DNMT1 and VEGFA loci in HEK293T, HeLa, and U2OS cells. b, Percentages of prime editing outcomes at HEK3 locus in HEK293T cells. c, Fold changes in intended prime editing. Editing percentages in Fig. 4c. d, Percentages of editing outcomes produced by PEmax or PE7 with the PE2 approach at on- and off-target sites using pegRNAs targeting the EMX1 (top left), HEK4 (top right), FANCF (bottom left), and HEK3 (bottom right) loci in U2OS cells. On-target editing data also presented in Fig. 4c and Extended Data Fig. 11a. Editing components delivered by plasmid transfection in a-d. Data and error bars in a, b and d indicate mean ± s.d. (n = 3 independent biological replicates). Horizontal bars in c indicate medians (8 edits) of ratios of means (n = 3 independent biological replicates for each edit). P-values in d are from two-tailed unpaired Student’s t-test.