Fig. 3. Application of CUPiD to cfDNA from 41 patients with CUP.

a Alluvial plot showing how the tumour type-enriched alterations (TTEAs) (left) and CUPiD predictions (right) correspond to clinical classifications (centre) (QC=Quality control). b Distribution of tumour types predicted by CUPiD (n = 32), excluding unclassified predictions. c Alluvial plot showing CUPiD predictions and correlation with subsequent primary tumour diagnosis or clinical suspicion (iCCA intrahepatic cholangiocarcinoma, Gyn gynaecological cancer, CRC colorectal cancer, cCUP confirmed Cancer of Unknown Primary). Class abbreviations are defined in Table 1. Source Data are provided as a Source Data file.