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. 2024 Apr 17;14:8902. doi: 10.1038/s41598-024-58536-3

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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(A) Verification results of upregulated miRNA. The Fold Change bar graph shows expression of SMAD2, TGFBR2, 3184-5p, and 423-5p genes. (B) TargetScanHuman figure for the 3′ UTR of the TGFβ R2, and SMAD 2. The 3′-UTR profile on the top presents the relative expression of 3′-UTR isoforms and the total number of 3P-seq reads. The profile presents Gencode annotation (red line), the conserved sites of the predicted target of miRNAs (boxes). The predicted site of miRNA up-regulation is miR-423-5p and miR-3184-5p(red boxes).