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. 2024 Apr 17;15:2909. doi: 10.1038/s41467-023-44166-2

Fig. 2. Monocyte and T-cell activation in HEU and HIV-unexposed children at 1 month of age.

Fig. 2

Bars at mean with 95% confidence intervals. Compared using fractional regression. P-values adjusted for infant sex, exact age at time of blood collection and randomised trial arm. All statistical tests are two-sided, and presented P-values have not been adjusted for multiple comparisons. A comparison of soluble CD14 between HEU and HIV-unexposed children; B comparison of soluble CD163 between HEU and HIV-unexposed children; C comparison of CD8+ T-cell activation between HEU and HIV-unexposed children; D comparison of CD8+ T-cell proliferation between HEU and HIV-unexposed children; E–H comparison of CD8+ T-cell differentiation between HEU and HIV-unexposed children; I, J comparison of CD8+ T-cell senescence between HEU and HIV-unexposed children; K comparison of CD8+ T-cell exhaustion between HEU and HIV-unexposed children; L–N comparison of monocyte subsets between HEU and HIV-unexposed children; O comparison of CD4+ T-cell activation between HEU and HIV-unexposed children; P comparison of CD4+ T-cell proliferation between HEU and HIV-unexposed children; Q–T comparison of CD4+ T-cell differentiation between HEU and HIV-unexposed children; U, V comparison of CD4+ T-cell senescence between HEU and HIV-unexposed children; W comparison of CD4+ T-cell exhaustion between HEU and HIV-unexposed children. Classical monocytes: CD3−/CD19−/CD20−/CD56−/HL-DR+/CD14++/CD16−; intermediate monocytes: CD3−/CD19−/CD20−/CD56−/HLADR+/CD14++/CD16+; non-classical monocytes: CD3−/CD19−/CD20−/CD56−/HLADR+/CD14+/CD16++. Non-senescent: CD28+/CD57-; senescent: CD28-/CD57+; exhausted: PD-1+. Activated: CD38+/HLA-DR+; proliferating: Ki67+. HEU: HIV-exposed uninfected. Blue: HEU children; red: HIV-unexposed children. Source data are provided as a Source Data file.