Fig. 5.

The tumor immune microenvironment analysis in SNUC tumor samples. A. Quantification of NK cells per mm² in 14 SNUC tumor samples. B. Increased interactions between CK^low tumor cells and NK cells in the tumor parenchyma are associated with no disease recurrence C. Increased interactions between CK^low tumor cells and NK cells in stroma are associated with no disease recurrence. D. Quantification of CK⁺PD-L1⁺, CD3⁺CD8⁺ and CD68⁺ cells per mm² in 14 SNUC tumor samples. E. Patients with high CD3⁺CD8⁺ in stroma show significantly better 5-year overall survival rate (P = 0.0029). F. High CK^low cells in tumor and CD8⁺ in stroma interactions are associated with longer term survival. *P ≤ 0.05.