Mirhosseini 2013.
Methods | Prospective, double‐blind, RCT | |
Participants | Patients (n = 120) undergoing elective off‐pump coronary artery bypass graft. Mean age: 63.41 ± 10.71 heparin group and 60.80 ± 10.64 heparin plus aspirin group. Male/female: 42/18 and 41/19, respectively | |
Interventions | Intervention: aspirin (80 mg daily orally) plus heparin (5000 U unfractionated heparin every 8 hours subcutaneously) Control: heparin (5000 U unfractionated heparin every 8 hours subcutaneously) Study treatments were given from admission to discharge |
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Outcomes | Deep vein thrombosis, bleeding, and pulmonary embolism All participants underwent right and left leg venous ultrasound examination during hospitalisation |
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Notes | Conflict of interest: none declared | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | Method of sequence generation not reported. Quote: "The patients were randomly assigned into two groups" |
Allocation concealment (selection bias) | Unclear risk | Method of allocation concealment not reported. Quote: "The patients were randomly assigned into two groups" |
Blinding of participants and personnel (performance bias) All outcomes | Low risk | Quote: "The nurse (observer) who took the medicine to the patients (participants) and the patients themselves were blinded." |
Blinding of outcome assessment (detection bias) All outcomes | Unclear risk | Blinding of outcome assessment not reported. Quote: "Ultrasonography was performed by an experienced and expert physician" |
Incomplete outcome data (attrition bias) All outcomes | Low risk | From Table 3 (Mirhosseini 2013), it appears that all participants randomised were included in the analysis |
Selective reporting (reporting bias) | Unclear risk | Outcomes are not clearly specified in the methods. Quote: "...post‐operation early complications such as bleeding and pulmonary embolism (PE), were recorded." |
Other bias | Unclear risk | It is unclear if participants were consecutively included. Risk factors for VTE are poorly reported |