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. 2024 Apr 11;38:101710. doi: 10.1016/j.bbrep.2024.101710

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© 2024 The Authors. Published by Elsevier B.V.

This is an open access article under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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Fig. 1 — Effect of Lipo-P4 on B-cell engraftment in humanized mice. (A) Protocol for Lipo-P4 evaluation using PBL-NOG-hIL-4-Tg. (B) Typical FACS patterns of human CD45⁺ leukocytes in the humanized mouse spleen (n = 4). The numbers shown in each panel are the percentages of the gated cells. Left two panels: expression of CD5 and CD19 in the human CD45⁺ cell-gated cells. Middle two panels: expression of CD27 and CD38 in the human CD19⁺ cell-gated cells shown in the left panels. Human CD19 (B cells), CD5 (T cells and B1 cells), CD27 (memory and plasmablast B cells), and CD38 (plasmablast and plasma cells). Right four panels: expression of PD-L1 in CD5⁺ T cells (left panels) and CD5⁻ B cells (right panels).