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. 2024 Mar 21;44(4):469–490. doi: 10.1002/cac2.12534

FIGURE 2.

FIGURE 2

hnRNPA2B1 induced chemoresistance by promoting proliferation and inhibiting apoptosis in vitro. (A) Western blotting and qPCR were used to detect the knockdown efficiency of hnRNPA2B1 in SGC7901VCR cells. (B‐D) IC50 values (B) and apoptosis (C and D) of SGC7901VCR shNC and SGC7901VCR shA2B1 cells treated with VCR and 5‐Fu. (E) Growth curves of SGC7901VCR shNC and SGC7901VCR shA2B1 cells treated without or with chemotherapy. (F) Western blotting and qPCR were used to detect the overexpression efficiency of hnRNPA2B1 in SGC7901 cells. (G‐I) IC50 values (G) and apoptosis (H and I) of SGC7901 lv‐NC and SGC7901 lv‐A2B1 cells treated with ADR, VCR and 5‐Fu. (J) Growth curves of SGC7901 lv‐NC and SGC7901 lv‐A2B1 cells treated without or with chemotherapy. The data are presented as the mean ± SEM. ** P < 0.01, *** P < 0.001 by one‐way ANOVA test (A), paired t test (D, F and I) and one‐way ANOVA with Dunnett's multiple‐comparison test (B, E, G and J). Abbreviations: hnRNPA2B1, heterogeneous nuclear ribonucleoprotein A2B1; IC50, half‐maximal inhibitory concentration; lv‐NC, empty overexpression control; lv‐A2B1, overexpression of hnRNPA2B1; shNC, negative control short hairpin RNA; shA2B1, short hairpin RNA of hnRNPA2B1.