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. 2024 Mar 21;44(4):469–490. doi: 10.1002/cac2.12534

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© 2024 The Authors. Cancer Communications published by John Wiley & Sons Australia, Ltd. on behalf of Sun Yat‐sen University Cancer Center.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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hnRNPA2B1 promoted cancer stemness‐like properties in vitro. (A) The expression of hnRNPA2B1 was correlated with mRNAsi scores in the TCGA GC dataset. (B‐C) qPCR and IF illustrated that regulation of hnRNPA2B1 resulted in corresponding changes in the expression of GCSC surface markers and pluripotent transcription factors in SGC7901^ADR, SGC7901^VCR, and parental SGC7901 cells. *P < 0.05, ** P < 0.01, *** P < 0.001, ns, not significant. Abbreviations: CD133, cluster of differentiation 133; CD44, cluster of differentiation 44; EpCAM, epithelial cell adhesion molecule; GCSC, gastric cancer stem cell; hnRNPA2B1, heterogeneous nuclear ribonucleoprotein A2B1; lv‐NC, empty overexpression control; lv‐A2B1, overexpression of hnRNPA2B1; LGR5, leucine‐rich repeat‐containing G‐protein coupled receptor 5; Nanog, homeobox protein Nanog; Oct4, octamer‐binding protein 4; shA2B1, short hairpin RNA of hnRNPA2B1; shNC, negative control short hairpin RNA; Sox2, SRY‐box transcription factor 2.