Table 5.

NMA results sorted based on GRADE certainty of evidence for the comparisons of active augmentation strategies versus placebo for Schizophrenia refractory/partially responding to clozapine

Outcome	Certainty of evidence	Classification	Intervention	MD (95% CrI)
Reduction in PANSS/BPRS	High (high and moderate)	Amongst the most effective	Mirtazapine	−5.2 (−7.7, −2.7)
			Memantine	−2.1 (−4.0, −0.19)
		Amongst the least effective	Glycine	−0.07 (−1.89, 1.78)
	Low (low and very low)	May be more effective than placebo	None

NMA, network meta-analysis; PANSS, positive and negative syndrome scale; BPRS, brief psychiatric rating scale; CI, confidence interval; CrI, credible intervals; MD, mean difference.