Table 1.
Baseline clinical characteristics
| Variable | All Patients (n = 1098) | European (n = 725) | North American (n = 373) | P value |
|---|---|---|---|---|
| Age (years) | 40.3 (±15.8) | 42.3 (±15.7) | 36.3 (±15.2) | <.0001 |
| Female sex | 549 (50.0%) | 330 (45.5%) | 219 (58.7%) | <.0001 |
| Male sex | 549 (50.0%) | 395 (54.5%) | 154 (41.3%) | <.0001 |
| History of syncope | 117 (10.7%) | 78 (10.8%) | 39 (10.5%) | .88 |
| # ECG leads w/ TWI | 3.5 (±2.2) | 3.6 (±2.2) | 3.3 (±2.1) | .051 |
| log(PVC count) | 6.6 (±2.5) | 6.7 (±2.4) | 6.2 (±2.8) | .0072 |
| History of NSVT | 454 (46.9%) | 293 (45.5%) | 161 (49.7%) | .38 |
| RVEF (%) | 43.6 (±10.9) | 43.9 (±11.0) | 43.1 (±10.8) | .21 |
| LVEF (%) | 56.3 (±9.3) | 55.6 (±9.5) | 57.7 (±8.5) | .0006 |
| LVEF < 50% | 186 (16.9%) | 135 (18.6%) | 51 (13.7%) | .038 |
| LVEF < 35% | 34 (3.1%) | 27 (3.7%) | 7 (1.9%) | .094 |
| 5-year VA risk (ARVC calculator %) | 19.3 [10.3; 36.5] | 19.2 [10.4; 33.7] | 19.7 [9.8; 39.9] | .59 |
| Genetic testing | 857 (78.1%) | 515 (71.0%) | 342 (91.7%) | <.0001 |
| Proband status | 640 (58.3%) | 446 (61.5%) | 194 (52.0%) | .0025 |
| Gene: PKP2 | 389 (45.4%) | 234 (45.4%) | 155 (45.3%) | .97 |
| Gene: DSP | 73 (8.5%) | 43 (8.3%) | 30 (8.8%) | .83 |
| Gene: PLN | 29 (3.4%) | 24 (4.7%) | 5 (1.5%) | .011 |
Variables are expressed as frequency (%), mean ± standard deviation, or median (IQR). Total number of patients for a given variable mentioned if missing data.
PKP2, plakophilin-2; DSP, desmoplakin; PLN, phospholamban.