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Desferrioxamine B (DFO) based prosthetic groups for thiol- or amino- based 89Zr radiolabeling of trastuzumab antibody and pharmacokinetic study using PET imaging. Schematic structure of (A) Desferrioxamine B (DFO), (B) DFO-CHx-Mal, (C) DFO-Iac, (D) DFO-N-Suc-TFP, and (E) DFO-Bz-SCN. (F) PET imaging data were acquired for all four 89Zr-trastuzumab derivatives using BT474M1 xenograft models (96 h post intravenous injection). Adapted with permission from 43, copyright 2010, Elsevier Inc.
