TABLE 1.
Pharmacokinetic parameters of V-PYRRO/NO and V-PROLI/NO after i.v. and i.p. administration in control mice
| Parameter | V-PYRRO/NO |
V-PROLI/NO |
||
|---|---|---|---|---|
| Intravenous | Intraperitoneal | Intravenous | Intraperitoneal | |
| Co (µM) | 41.5 | — | 222.48 | — |
| AUC0→∞ (µM*min) | 218.62 | 60.9 | 5669.26 | 2895.27 |
| MRT (min) | 6 | 7.7 | 27.87 | 28.57 |
| Cmax (µM) | — | 7.93 | — | 79.57 |
| tmax (min) | — | 5 | — | 10 |
| Vss (l/kg) | 0.88 | — | 0.149 | — |
| Cl (l/min/kg) | 0.146 | — | 0.0053 | — |
| F (%) | — | 27.85 | — | 51.07 |
AUC0→∞, area under the curve extrapolated to infinity; Cl, clearance; Co, initial concentration; MRT, mean residence time; tmax, the time to reach the maximum plasma concentration; Vss, steady-state volume of distribution.