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Schematic of ADC catabolism. The catabolic pathway includes ADC (A) binding to tumor antigen (B); internalization of the ADC-tumor antigen complex into the endosome (noncleavable linker is stable) (C); a portion of the endosome is sorted to the lysosome where ADC is catabolized (D); and the catabolite exits the lysosome (E) and binds to microtubulin (F).
