Table 4. Physical Evaluation of Blank Gel, NLC Gel, and ZOE-NLC Gel Formulations at Room Temperature.
| formulation | physical appearance | drug content (% w/w) | % yield | homogeneity | pH | |
|---|---|---|---|---|---|---|
| day 1 | day 90 | |||||
| blank gel | transparent | NA | 78.3 | homogenous, no visible phase separation | 6.31 ± 0.01 | 6.55 ± 0.06 |
| NLC gel | cloudy | NA | 76.1 | 5.22 ± 0.12 | 5.74 ± 0.08 | |
| ZOE-NLC gel | cloudy/semitransparent | 74.0 | 5.53 ± 0.07 | 5.64 ± 0.02 | ||