Table 1.
Basic characteristics of the included studies
| Study | Country | Animal characteristics | Model | Modeling material | Method of administration | Dose of quercetin | T | E | C | Outcome measures |
|---|---|---|---|---|---|---|---|---|---|---|
| Neisy A.,2019 [14] | Iran | female SD rats (180 g) | PCOS | DHEA | Be injected with 6 mg/100 g/d DHEA dissolved in 0.2 ml sesame oil for 21 days to induce PCOS | 15 mg/kg Q dissolved in 0.5 mL 10% ethanol | 30d | Q | Didn’t receive any treatment | ①②③⑫ |
| Shah M.Z.U.H.,2023 [15] | India | mature parkes strain mice (18–21 g) | PCOS | LETZ | Be given 6 mg/kg LETZ for 21 days to induce PCOS | 125 mg/kg Q | 45d | Q | Didn’t receive any treatment | ④⑤⑥⑧⑨ |
| Zheng S.Y.,2022 [16] | China | female SD rats (21-day-old) | PCOS | DHEA | Be injected with 6 mg/100 g/d DHEA dissolved in 0.2 ml sesame oil for 20 days to induce PCOS | 100 mg/kg Q dissolved in 2 ml 1% sodium carboxymethyl cellulose solution | 28d | Q | 2 ml 1% sodium carboxymethylcellulose solution | ③⑥⑦⑧ |
| Wang Z.Z.,2017 [17] | China | female Wistar rats (21-day-old) | PCOS | DHEA | Be injected with 6 mg/100 g/d DHEA dissolved in 0.2 ml sesame oil for 20 days to induce PCOS | 2 mL of Q solution (100 mg/kg) | 28d | Q | 2 mL of 1% CMC | ②③ |
| Olaniyan O.T.,2020 [8] | Nigeria | prepubertal female Wistar rats (21-day-old) (18 ± 1.58 g) | PCOS | DHEA | Be injected with 6 mg/100 g/d DHEA dissolved in 0.2 ml corn oil to induce PCOS | 100 mg/kg Q | 15d | Q | Didn’t receive any treatment | ⑨⑩⑪ |
| Mahmoud A.A.,2022 [18] | Egypt | prepubertal female Wistar rats (23-day-old) (26.45 ± 0.06 g) | PCOS | DHEA | Be injected wtih 60 mg/kg DHEA dissolved in 1 ml sesameoil for 41 days to induce PCOS | 25 mg/kg Q dissolved in 0.05 ml saline | 28d | Q | saline | ⑥⑦⑧ |
| Mihanfar A.,2021 [19] | Iran | female Wistar rats (42-day-old) | PCOS | LETZ | Be given 1 mg/kg LETZ dissolved in CMC 0.5% for 21 days to induce PCOS | 100 mg/kg Q dissolved in CMC 0.5% | 30d | Q | Didn’t receive any treatment | ①②③④⑤⑥ |
| Jahan S.,2018 [20] | Pakistan | adult female SD rats (60-70-day-old) (180 ± 10 g) | PCOS | LETZ | Be given 1 mg/kg LETZ dissolved in 0.5% CMC to induce PCOS | 30 mg/kg Q | 22d | Q | Didn’t receive any treatment | ④⑤⑪ |
| Jiang X.J.,2022 [21] | China | SPF female SD rats (21-23-day-old) | PCOS | LETZ | Be given 1 mg/kg LETZ dissolved in 0.4 ml CMC to induce PCOS | 30 mg/kg Q dissolved in 0.5 mL 10% ethanol | 28d | Q | 0.5 mL 10% ethanol | ①②⑫ |
| Yang Z.,2021 [22] | China | minor female SD rats (21-day-old) (80–90 g) | PCOS | DHEA | Be injected with 6 mg/100 g/d DHEA dissolved in 0.2 ml olive oil for 20 days to induce PCOS | 100 mg/kg Q dissolved in 2 ml CMC | 1d | Q | 2 mL CMC | ⑥⑦⑩⑪ |
Abbreviations SD: Sprague–Dawley; Q: quercetin; PCOS: polycystic ovary syndrome; DHEA: dehydroepiandrosterone; LETZ: letrozole; CMC: carboxy methylcellulose; T: time; E: experimental group; C: control group
Notes ① Fasting insulin serum levels; ② fasting blood glucose levels; ③ HOMA-IR; ④ cholesterol levels; ⑤ triglyceride levels; ⑥ testosterone levels; ⑦ luteinizing hormone levels; ⑧ luteinizing hormone/follicle stimulating hormone ratio; ⑨ vascular endothelial growth factor levels; ⑩ malondialdehyde levels; ⑪ superoxide dismutase levels; and ⑫ the expression of GLUT4 mRNA