Table 1.
Demographic and clinical parameter, treatment and outcome of children and adolescents in the study sample
| Parameter | Patients ≥ 12 years | Patients < 12 years |
|---|---|---|
| N | 674 | 682 |
| Female subjects, n (%) | 456 (67.7) | 483 (70.8) |
| Age, years, mean (SD) | 15.2 (1.9) | 7.2 (2.9) |
| Age at disease onset, years, mean (SD) | 8.8 (4.9) | 4.3 (2.8) |
| Disease duration, years, mean (SD) | 6.4 (4.9) | 2.9 (2.7) |
| Diagnoses, n (%) | ||
| JIA | 6201 | 6592 |
| Systemic arthritis | 24 (3.6) | 34 [5] |
| Oligoarthritis, extended | 73 (10.8) | 64 (9.4) |
| Oligoarthritis, persistent | 214 (31.8) | 355 (52) |
| Psoriatic arthritis | 44 (6.5) | 24 (3.5) |
| Enthesitis-related arthritis | 85 (12.6) | 19 (2.8) |
| Polyarthritis, seropositive | 19 (2.8) | 11 (1.6) |
| Polyarthritis, seronegative | 127 (18.8) | 124 (18.2) |
| Other arthritis | 26 (3.9) | 21 (3.1) |
| Systemic lupus erythematosus | 42 (6.2) | 6 (0.9) |
| Juvenile dermatomyositis | 12 (1.8) | 17 (2.5) |
| ANA positive/tested, n (%) | 341/556; (61) | 37/524; (71) |
| Therapy, n (%)* | ||
| DMARD | 352 (55.5) | 346 (55) |
| sDMARD | 262 (41.3) | 290 (46.1) |
| bDMARD | 195 (30.8) | 124 (19.7) |
| Systemic glucocorticoids | 35 (6.2) | 24 (4.8) |
| Outcome parameter | ||
| PhGA disease activity, NRS, mean (SD) | 1.3 (1.8) | 1.5 (2.2) |
| Joint count, mean (SD)# | 1.1 (2.9) | 1.2 (3.3) |
| Functional status, CHAQ (0–3), mean (SD) | 0.2 (0.5) | 0.3 (0.5) |
| PGA, NRS, mean (SD) | 2.3 (2.5) | 2.1 (2.5) |
JIA: juvenile idiopathic arthritis; ANA: antinuclear antibodies; DMARD: disease modifying antirheumatic drugs; sDMARD: synthetic (conventional and targeted) disease modifying antirheumatic drugs; bDMARD: biologic disease modifying antirheumatic drugs; PhGA: physician`s global assessment of disease activity; PGA: Patient`s global assessment of health status *Percentages according to available valid information on the medication; #only determined in JIA patients, n = 1279. 1There was a diagnosis of oligoarthritis without indication of persistent or extended in 5 cases, a diagnosis of polyarthritis without information on rheumatoid factor in 2 cases, and a diagnosis of JIA without indication of category in 1 case, which therefore could not be assigned. 2There was a diagnosis of oligoarthritis without indication of persistent or extended in 4 cases, a diagnosis of polyarthritis without information on rheumatoid factor in 1 case, and a diagnosis of JIA without indication of category in 2 cases