Fig. 3.

FLMs and permutation F-tests comparing 24-h activity profiles between high and low TAQ overactivity groups

Upper panels for each syndrome present the mean 24-hour activity profile of the high and low TAQ groups, converted to functional form via Fourier expansion model. Lower panels present the permutation F-test output. Results were considered significant where the observed statistic (red line) is greater than the maximum critical value (horizontal dashed blue line). a Angelman syndrome, b Smith-Magenis syndrome, c tuberous sclerosis complex