Table 2.

Parameter sets in the simulation study. All parameters considered in the simulation are listed and their true values are shown for scenarios 1 to 6 of Section 4.1. For log-scaled parameters of Section 2.2, back-transformed values, that is, ratios, are shown in the table. The expected value of the Cox model HR estimate is shown for comparison. For the score test, the expected contribution of an individual to the summed score statistic is shown. Cross-marks (x) indicate which parameter is included in which set.

			Scenario						Parameter set
Parameter	Interpretation	Time	1	2	3	4	5	6	1	2	3	4	5	6	7
S	Survival diff.	1	0.00	−0.06	−0.06	0.12	0.12	0.17		x			x
S		2	0.16	0.16	0.16	0.15	0.10	0.15		x			x
S		3	0.20	0.29	0.29	0.15	0.09	0.10		x			x
logS	Survival ratio	1	1.00	0.92	0.92	1.19	1.34	1.35			x
logS		2	1.41	1.43	1.43	1.42	1.63	1.70			x
logS		3	2.28	3.29	3.29	1.69	1.74	2.05			x
Q	25% qu. diff.		0.10	-0.26	-0.26	0.31	0.09	0.29		x
logQ	25% qu. ratio		1.09	0.74	0.74	1.54	1.29	1.71			x
RMST	RMST diff.	3	0.26	0.20	0.20	0.36	0.28	0.40	x	x	x				x
cloglogS	Cumulative HR	1	1.00	1.28	1.28	0.65	0.73	0.60				x		x
cloglogS		2	0.63	0.64	0.64	0.65	0.73	0.65				x		x
cloglogS		3	0.56	0.43	0.43	0.65	0.74	0.69				x		x
avgHR	Average HR	3	0.67	0.75	0.75	0.65	0.74	0.62	x			x			x
HR	Cox model HR	3	0.63	0.62	0.69	0.65	0.73	0.64
score	Score test	3	-0.07	-0.07	-0.05	-0.06	-0.06	-0.08					x	x	x

HR: hazard ratio; avgHR: average HR: RMST: restricted mean survival time; cloglogS: complementary log–log scenario.