Table 5.

Analysis of example data based on Figure 2D of Burtness et al. ²² Selected parameters of the survival function under pembrolizumab and cetuximab are compared using unadj confidence intervals, simultaneous confidence intervals with adjustment based on the MVN distribution (MVN adjusted) and Bonferroni-adjusted intervals.

				95% Confidence intervals
Parameter	Pembro.	Cetux.	Difference	Unadjusted	MVN adjusted	Bonferroni
0.5-year survival	0.721	0.763	−0.042	[−0.112, 0.028]	[−0.129, 0.044]	[−0.134, 0.049]
1-year survival	0.514	0.465	0.049	[−0.030, 0.129]	[−0.049, 0.148]	[−0.056, 0.155]
2-year survival	0.277	0.189	0.088	[0.021, 0.155]	[0.005, 0.171]	[−0.001, 0.177]
Median survival	1.037	0.915	0.122	[−0.075, 0.319]	[−0.121, 0.365]	[−0.136, 0.381]
3.5-year RMST	1.436	1.232	0.204	[0.027, 0.381]	[−0.015, 0.422]	[−0.029, 0.437]

unadj: unadjusted; MVN: multivariate normal; RMST: restricted mean survival time.