Fig 4.

Sequence similarity network of the YtqA/YhcC family. (A) The radical SAM domains that are fused to MnmC2 are members of the Megacluster-2-4-1 (in black), on RadicalSAM.org a subgroup of Megacluster-2–4 ((Elongator protein-like); (B) YtqA/YhcC SSN overview generated using InterPro HMM signature identifier IPR005911 (EFI-EST; AS100, repnode 55). Different types of data were mapped to the subset of nodes (black outlines) present in the benchmark genomes (968 representative genomes that encode MnmAGE proteins): (1) Presence/absence data of MnmC1, MnmC2, and MnmC1/C2 fusions (Data S3); (2) YtqA/MnmC2 fusions data (Data S3); (3) physical clustering data (Data S5). Dark blue nodes were found to be without Gene Cluster data in KEGG. For complete mapping, see Data S8.