Table 2. Univariate and multivariate Cox regression analyses of the overall survival of glioma patients.

Characteristics	Total (N)	Univariate analysis		Multivariate analysis
		Hazard ratio (95% CI)	P value	Hazard ratio (95% CI)	P value
Age	698
≤60 years old	555	Reference		Reference
>60 years old	143	4.696 (3.620–6.093)	<0.001***	1.429 (1.046–1.952)	0.025*
Gender	698
Female	297	Reference		Reference
Male	401	1.250 (0.979–1.595)	0.073	1.185 (0.903–1.553)	0.220
WHO grade	636
G2	223	Reference		Reference
G3	245	2.967 (1.986–4.433)	<0.001***	1.873 (1.223–2.868)	0.004**
G4	168	18.600 (12.448–27.794)	<0.001***	4.253 (2.525–7.162)	<0.001***
IDH status	688
WT	246	Reference		Reference
Mutation	442	0.116 (0.089–0.151)	<0.001***	0.265 (0.176–0.399)	<0.001***
1p/19q codeletion	691
Non-codel	520	Reference		Reference
Codel	171	0.225 (0.147–0.346)	<0.001***	0.843 (0.494–1.440)	0.533
GPR27	698
Low	349	Reference		Reference
High	349	0.326 (0.251–0.423)	<0.001***	0.679 (0.486–0.947)	0.023*

Notes.

^*P¡0.05

^**P¡0.01

^***P¡0.001