Fig. 1.
Cryo-electron microscopy image of mGlu7 homodimer with accompanying downstream molecular pathways associated with receptor activation in response to high synaptic levels of glutamate. Structure PDB ID: 7EPC from Du et al. (2021). Structures of human mGlu2 and mGlu7 homo- and heterodimers (Du et al., 2021). Figure created with BioRender.com. CaMKII, calmodulin-dependent kinase II; CREB, cAMP response element binding protein; ERK, extracellular-regulated kinase; GIRK, G-protein coupled inwardly rectifying potassium channel; JNK, c-Jun N-terminal kinase; MEK, mitogen-activated protein kinase kinase; MEKK, mitogen-activated protein kinase kinase kinase; mGlu7, metabotropic glutamate receptor 7; MKK4, mitogen-activated protein kinase kinase 4; MKK7, mitogen-activated protein kinase kinase 7; PICK1, protein interacting with C kinase 1; PKCα, protein kinase C alpha.