Fig. 3.

Metabotropic glutamate receptor group III and mGlu₇-selective tool compounds organized by their mode of pharmacology. All orthosteric agonists are active at all group III receptors, aside from LSP2-9166, which is active at mGlu₄ and mGlu₇ and only active at mGlu₈ at high concentrations (Acher et al., 2012; Amalric et al., 2013; Hajasova et al., 2018). AMN082 is a selective allosteric agonist (Mitsukawa et al., 2005), while CVN636 (Dickson et al., 2023) and the series of compounds published by Cid et al. (Cid et al., 2019) are also selective, with more favorable in vivo parameters. NAMs shown are active at mGlu₇ homodimers, with some displaying activity at mGlu_7/8 heterodimers as well (Reed et al., 2020; Lin et al., 2022). VU0155094 and VU0422288 are group III mGlu receptor-selective PAMs (Jalan-Sakrikar et al., 2014), VU6005649 is a dual mGlu₇/mGlu₈ PAM, and VU6027459 is an mGlu₇-selective PAM (Reed et al., 2020). VU6046980 is a highly mGlu₇-selective PAM derived from VU6027459 (Kalbfleisch et al., 2023). Figure created with Biorender.com.