Fig. 1. Overall structures of the CXCR3–CXCL11–DNGi-scFv16, CXCR3–PS372424–DNGi-scFv16, CXCR3–VUF11222–DNGi-scFv16 and CXCR3κOR–SCH546738-Nb6 complex.
a–c, Density maps and cartoon models of CXCR3–CXCL11–DNGi-scFv16 (a), CXCR3–PS372424–DNGi-scFv16 (b) and CXCR3–VUF11222–DNGi-scFv16 (c). Receptor, ligand, DNGαi, Gβ, Gγ and scFv16 are colored violet, cyan, blue, green, orange and gray, respectively. PS372424 and VUF11222 are shown as spheres. d, Density map and cartoon model of CXCR3κOR–SCH546738-Nb6. CXCR3, κOR fragment, SCH546738 and Nb6 are colored violet, orange, cyan and gray, respectively. SCH546738 is shown with spheres.