Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2024 Jan 4;31(4):610–620. doi: 10.1038/s41594-023-01175-5

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Extended Data Fig. 8 — a Superposition of the β-arrestin-coupled and G protein-coupled 5HT2B. b Superposition of the β-arrestin-coupled and G protein-coupled ACM2. c Superposition of the β-arrestin-coupled and G protein-coupled NTR1. In a-c, the receptors are shown as cartoon, and colored cyan for β-arrestin-coupled receptor and gray for G protein-coupled receptor. The Cα atoms of 7.47 and 7.53 are shown as spheres, and the side chains of 7.53 are shown as sticks. The tilt in TM7^7.47-7.53 is indicated by black arrows. d Superposition of Gi-coupled CXCR3 activated by CXCL11 (violet), PS372424 (yellow), and VUF11222 (blue). e The tilt of TM7^7.47-7.53 initiated by the insertion of VUF11222. f A proposed model for the mechanism for the biased signaling of CXCR3.