Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2024 Jan 4;31(4):610–620. doi: 10.1038/s41594-023-01175-5

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 3 — a, The chemical structure of PS372424. b, A general view of the PS372424 binding site in CXCR3. PS372424 and CXCR3 are shown as stick model (colored gray) and surface model (colored by electronic potential), respectively. c, Interactions between PS372424 (gray) and CXCR3 (yellow). PS372424 and the residues involved in interactions are shown as sticks. Green dashes indicate interactions. d, cAMP responses of CXCR3 mutants to PS372424. cAMP responses are normalized to the percentage agonist activity of wild-type CXCR3. The data represent means ± s.e.m. (n = 3 independent experiments). The expression level of CXCR3 mutants is shown in Extended Data Fig. 4b and the corresponding EC₅₀ is shown in Extended Data Table 1.

Source data