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. 2023 Sep 6;26(5):1043–1062. doi: 10.1007/s12094-023-03307-1

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Mature B-cell malignancies: cell of origin and main genetic alterations. Schematic representation of B-cell maturation process throughout the germinal center from naïve B-cells to memory and plasma B-cells, and their derived mature B-cell lymphoma. The recently proposed genetic subtypes for DLBCL are represented in the lower part of the figure, with the genes defining each subtype and the relationship with the DLBCL COO classification. The most relevant mutated genes are indicated in the box associated with each subtype. U-unmutated; M-mutated; CLL chronic lymphocytic leukemia; MCL mantle cell lymphoma; FL follicular lymphoma; MZL marginal zone lymphoma; DLBLC diffuse large B cell lymphoma; BL Burkitt’s lymphoma; DH Double hit; HL Hodgkin lymphoma; LPL/WM lymphoplasmacytic lymphoma/Waldenström macroglobulinemia; FDC follicular dendritic cells; COO cell-of-origin; GCB germinal center B cell; ABC activated B cell