Table 4.

Proposed next-generation sequencing panels for B- and T-cell lymphomas

B-cell lymphomas							T-cell lymphomas
Mandatory		Recommended		CNAs			Mandatory		Recommended		CNAs
B2M	KTM2D	ARID1A	MEF2B	ATM	CN gain	11p	CD28	RHOA	ARID1A	NOTCH1	TP53	CN loss	17p13.1
BCL10	MYC	ARID1B	MKLN1	BCL2	CN gain	18q21.33	DNMT3A	SETD2	CTCF	PREX2	MYC	CN gain	8q24.21
BCL2	MYD88	ATM	NFKBIE	BCL6	CN gain	3q27.3	IDH2	STAT3	FYN	PRKCQ	CDKN2A	CN loss	9p21.3
BCL6	NOTCH1	CD79A	NSD2	CDKN2A	CN loss	9p21.3	JAK1	STAT5B	IN080	RB1
BIRC3	NOTCH2	CSFR2B	P2RY8	FOXO1	CN gain	13q	JAK3	TET1	LCK	TET3
BTG1	PIM1	DDX3X	PLEKHG1	MYC	CN gain	8q24.21	PI3KCD	TET2	NFAT5	TRRAP
BTK	PIM2	FBXW7	POT1	TP53	CN loss	17p13.1	PLCG1	TP53	NFATC2
CARD11	PLCG2	FOXO1	PTPN11	CCND1	CN gain	11q13	PRDM1	VAV1
CCND3	POU2AF1	HIVEP2	S1PR2	Del (7q)	CN loss	7q31–32
CD58	PRDM1	IGLL5	SIN3A	TRISOMY 3	CN gain
CD70	SF3B1	IKBK	RPS15	TRISOMY 12	CN gain
CD79B	SGK1	IKZF3	TRAF2	TRISOMY 18	CN gain
CHD2	SOCS1	ITPKB	TRAF3
CREBBP	STAT3	LYN	XPO1
DTX1	STAT6	MAP2K1	ZMYM3
EP300	TCF3	MAP3K14	ZNF292
EZH2	TET2
GNA13	TNFAIP3
HIST1H1E	TNFRSF14
IRF8	TP53
ID3	UBE2A
KLF2	IGHV

CNAs Copy number alterations; CN Copy number