Fig. 5.

Proteomic profiling. A Provided are information about the protein modules associated with immune regulation, lipid metabolism, and steroid biosynthesis in the blood samples of the patient. Shown is a co-expression graph where each node represents a gene and edges represent co-expression scores, with thicker edges indicating stronger correlations between genes. Genetic distances between genes within a module are indicated by green lines. Genes shared by different modules are color-coded according to their function. In summary, immune regulatory processes, and lipid metabolism are most differentially regulated. B A score plot that depicts a principal component analysis (PCA) performed on the proteome of 55 individuals with CAD involved in the PRECAD study, as well as the patient (study subject, n = 1). C Heatmap of the log₂ abundances of the most abundant proteins in the patient (n = 1, four replicated denoted by N1.1–4), compared with the protein abundances of 55 matched individuals with CAD who participated in the PRECAD study. Protein identifiers are followed by their corresponding entrez gene names. In summary, clear differences are most significant regarding immune system-related traits. A2M alpha-2-macroglobulin, ALB albumin, APOA1 apolipoprotein A-I, HP haptoblobin, HPX hemopexin, IGHA1 immunoglobulin heavy constant alpha 1, IGKC immunoglobulin kappa constant, IGLC2 immunoglobulin lambda constant 2, SERPINA1 alpha-1-antitrypsin, TF serotransferrin