Table 1.
Summary of five cases with the application of mNGS in diagnosis of cat-scratch disease
| Author (Ref) | Age (yr)/Sex | Contact with cats | Clinical manifestation | Sample type | B. henselae-specific sequences (reads)a | Genome coverageb | Other microbiology |
|---|---|---|---|---|---|---|---|
| Yang et al. [10] | 48/Female | Yes | Intermittent fever, systemic rash, fatigue, anorexia, weight loss, shock and unconsciousness | Lymph node tissue | 7182 | 13.94% | NAc |
| Wang et al. [11] | 65/Male | NA | Fever, subcutaneous abcess | Tissue swab | 305 | 0.9% | Culture negative |
| Patel et al. [12] | 65/Male | Yes | Fever, shortness of breath and chest pain | Plasma | NA | NA | Culture negative, serology positive |
| Kassab et al. [13] | 49/Male | No | Fever, tensionlike headache, nausea, and non-bloody emesis | Cerebrospinal fluid | 22 | 0.13% | Culture negative, PCR negative, serology positive |
| Li et al. [14] | 13/Male | Yes | Intermittent fever, headache, poor appetite and weight loss | Peripheral blood | 4 | NA | Culture negative |
aThe specific and only mapped sequence number to the pathogen genome
bThe proportion of the sequence number covered the whole pathogen genome
cNot available