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. 2024 Apr 19;9:93. doi: 10.1038/s41392-024-01799-z

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — The results of cytokines detection of group-R (n = 5) and group-NR (n = 5) patients. The concentration values of EGF (a) and CTLA-4 (b) of patients in group-R (red) and group-NR (green) at every time point (T1–T4). c The clustering of two-group patients based on cytokines in the pre-treatment blood (T1). The concentration values of various cytokines at different time points (T1–T4) in group-R (d) and group-NR (e) patients. With *P < 0.05, **P < 0.01, ***P < 0.001 and ‘ns’ for no significant difference