TABLE 1.
Baseline characteristics according to MLR tertiles.
| NLR | Overall | Tertile 1 | Tertile 2 | Tertile 3 | p-value |
|---|---|---|---|---|---|
| (0.09–1.65) | (1.65–2.25) | (2.25–24.60) | |||
| N | 25,367 | 8,117 | 8,521 | 8,729 | |
| MLR | 0.31 ± 0.14 | 0.19 ± 0.04 | 0.28 ± 0.02 | 0.45 ± 0.15 | <0.001 |
| NLR | 2.25 ± 1.27 | 1.62 ± 0.76 | 2.03 ± 0.81 | 3.04 ± 1.58 | <0.001 |
| PLR | 125.78 ± 52.90 | 103.00 ± 36.58 | 118.22 ± 37.80 | 154.35 ± 64.32 | <0.001 |
| SII | 533.59 ± 394.90 | 390.80 ± 250.45 | 489.32 ± 380.92 | 709.57 ± 448.77 | <0.001 |
| SIRI | 1.34 ± 1.01 | 0.73 ± 0.33 | 1.16 ± 0.50 | 2.10 ± 1.30 | <0.001 |
| AISI | 324.46 ± 316.05 | 178.02 ± 107.64 | 284.64 ± 284.31 | 499.52 ± 385.33 | <0.001 |
| Age, years | <0.001 | ||||
| 20–40 | 8,728 (34.41%) | 3,494 (43.05%) | 3,170 (37.20%) | 2064 (23.65%) | |
| 41–60 | 8,276 (32.63%) | 2,940 (36.22%) | 2,901 (34.05%) | 2,435 (27.90%) | |
| > 60 | 8,363 (32.97%) | 1,683 (20.73%) | 2,450 (28.75%) | 4,230 (48.46%) | |
| Race, n (%) | <0.001 | ||||
| Mexican American | 4,326 (17.05%) | 1,620 (19.96%) | 1,580 (18.54%) | 1,126 (12.90%) | |
| Other Hispanic | 2000 (7.88%) | 666 (8.21%) | 753 (8.84%) | 581 (6.66%) | |
| Non-Hispanic White | 11,377 (44.85%) | 2,624 (32.33%) | 3,775 (44.30%) | 4,978 (57.03%) | |
| Non-Hispanic Black | 5,266 (20.76%) | 2,204 (27.15%) | 1,601 (18.79%) | 1,461 (16.74%) | |
| Other Races | 2,398 (9.45%) | 1,003 (12.36%) | 812 (9.53%) | 583 (6.68%) | |
| Education level, n (%) | 0.088 | ||||
| Less than high school | 6,963 (27.48%) | 2,278 (28.08%) | 2,384 (28.01%) | 2,301 (26.41%) | |
| High school or GED | 6,068 (23.95%) | 1913 (23.58%) | 2041 (23.98%) | 2,114 (24.26%) | |
| Above high school | 12,306 (48.57%) | 3,921 (48.34%) | 4,086 (48.01%) | 4,299 (49.33%) | |
| BMI, n (%) | 0.089 | ||||
| Normal weight | 7,014 (28.17%) | 2,254 (28.16%) | 2,303 (27.43%) | 2,457 (28.92%) | |
| Overweight | 9,656 (38.79%) | 3,092 (38.63%) | 3,246 (38.67%) | 3,318 (39.05%) | |
| Obese | 8,226 (33.04%) | 2,658 (33.21%) | 2,846 (33.90%) | 2,722 (32.03%) | |
| Smoking status, n (%) | <0.001 | ||||
| ≥100 cigarettes lifetime | 4,258 (52.48%) | 4,677 (54.94%) | 5,109 (58.61%) | 4,258 (52.48%) | |
| <100 cigarettes lifetime | 3,855 (47.52%) | 6,845 (84.33%) | 7,103 (83.36%) | 6,952 (79.64%) | |
| PIR, n (%) | <0.001 | ||||
| Low income | 2,402 (32.58%) | 2,537 (32.62%) | 2,686 (33.74%) | 2,402 (32.58%) | |
| Medium income | 2,775 (37.64%) | 2,949 (37.92%) | 3,152 (39.60%) | 2,775 (37.64%) | |
| High income | 2,195 (29.77%) | 2,291 (29.46%) | 2,122 (26.66%) | 2,195 (29.77%) | |
| Alcohol consumption, n (%) | 17,170 (78.26%) | 5,546 (80.09%) | 5,872 (79.37%) | 5,752 (75.51%) | <0.001 |
| Hypertension, n (%) | 14,569 (57.43%) | 4,216 (51.94%) | 4,663 (54.72%) | 5,690 (65.19%) | <0.001 |
| Diabetes, n (%) | 4,467 (17.61%) | 1,272 (15.67%) | 1,418 (16.64%) | 1777 (20.36%) | <0.001 |
| Eosinophil percentage, % | 3.09 ± 2.28 | 3.02 ± 2.25 | 3.10 ± 2.30 | 3.15 ± 2.29 | 0.001 |
| Basophils percentage, % | 0.71 ± 0.47 | 0.73 ± 0.52 | 0.71 ± 0.44 | 0.70 ± 0.45 | <0.001 |
| TC, mg/dL | 191.24 ± 42.06 | 195.64 ± 42.53 | 193.13 ± 41.35 | 185.34 ± 41.64 | <0.001 |
| ALT, U/L | 29.10 ± 27.19 | 29.66 ± 19.12 | 29.51 ± 24.65 | 28.17 ± 34.84 | <0.001 |
| AST, U/L | 27.20 ± 21.49 | 26.87 ± 15.39 | 26.90 ± 17.19 | 27.80 ± 28.85 | 0.006 |
| Triglyceride, mg/dL | 163.65 ± 139.56 | 179.26 ± 162.44 | 166.24 ± 144.80 | 146.64 ± 105.37 | <0.001 |
| Total bilirubin, mg/dL | 0.73 ± 0.34 | 0.72 ± 0.33 | 0.72 ± 0.32 | 0.74 ± 0.36 | <0.001 |
| Serum uric acid, mg/dL | 6.05 ± 1.33 | 5.99 ± 1.27 | 6.03 ± 1.30 | 6.12 ± 1.42 | <0.001 |
| Serum total calcium, mg/dL | 9.43 ± 0.37 | 9.45 ± 0.36 | 9.44 ± 0.36 | 9.40 ± 0.38 | <0.001 |
| PCa, n (%) | 787 (3.10%) | 137 (1.69%) | 179 (2.10%) | 471 (5.40%) | <0.001 |
MLR, monocyte-to-lymphocyte ratio; NLR, neutrophil-to-lymphocyte ratio; PLR, platelet-to-lymphocyte ratio; SII, systemic immune-inflammation index; SIRI, system inflammation response index; AISI, aggregate index of systemic inflammation; GED, general educational development; BMI, body mass index; PIR, family income to poverty ratio; TC, total cholesterol; ALT: alanine aminotransferase; AST: aspartate aminotransferase; PCa, prostate cancer.