TABLE 2.
Association between MLR and other inflammatory markers with PCa.
| Index | Continuous or categories | Model 1 c | Model 2 d | Model 3 e | |||
|---|---|---|---|---|---|---|---|
| OR a (95%CI b ) | p-value | OR (95%CI) | p-value | OR (95%CI) | p-value | ||
| MLR | Continuous variable | 11.65 (8.38, 16.20) | <0.0001 | 1.84 (1.25, 2.70) | 0.0019 | 2.28 (1.44, 3.62) | 0.0005 |
| Tertile 1 | Reference | Reference | Reference | ||||
| Tertile 2 | 1.25 (0.99, 1.56) | 0.0516 | 0.98 (0.78, 1.24) | 0.8750 | 0.90 (0.67, 1.19) | 0.4484 | |
| Tertile 3 | 3.32 (2.74, 4.03) | <0.0001 | 1.35 (1.09, 1.66) | 0.0057 | 1.35 (1.05, 1.74) | 0.0213 | |
| P for trend | <0.0001 | 0.0004 | 0.0012 | ||||
| NLR | Continuous variable | 1.20 (1.16, 1.25) | <0.0001 | 1.06 (1.02, 1.11) | 0.0080 | 1.10 (1.04, 1.16) | 0.0004 |
| Tertile 1 | Reference | Reference | Reference | ||||
| Tertile 2 | 1.44 (1.18, 1.76) | 0.0004 | 1.30 (1.05, 1.61) | 0.0164 | 1.34 (1.02, 1.74) | 0.0323 | |
| Tertile 3 | 2.47 (2.05, 2.97) | <0.0001 | 1.38 (1.13, 1.70) | 0.0018 | 1.60 (1.24, 2.06) | 0.0003 | |
| P for trend | <0.0001 | 0.0047 | 0.0004 | ||||
| PLR | Continuous variable | 1.01 (1.00, 1.01) | <0.0001 | 1.00 (1.00, 1.01) | <0.0001 | 1.00 (1.00, 1.01) | <0.0001 |
| Tertile 1 | Reference | Reference | Reference | ||||
| Tertile 2 | 1.16 (0.95, 1.41) | 0.1477 | 1.16 (0.94, 1.43) | 0.1636 | 1.09 (0.85, 1.41) | 0.5057 | |
| Tertile 3 | 2.14 (1.79, 2.55) | <0.0001 | 1.62 (1.34, 1.95) | <0.0001 | 1.76 (1.40, 2.21) | <0.0001 | |
| P for trend | <0.0001 | <0.0001 | <0.0001 | ||||
| SII | Continuous variable | 1.00 (1.00, 1.01) | <0.0001 | 1.00 (1.00, 1.01) | 0.0076 | 1.00 (1.00, 1.01) | 0.0013 |
| Tertile 1 | Reference | Reference | Reference | ||||
| Tertile 2 | 1.27 (1.05, 1.53) | 0.0143 | 1.32 (1.08, 1.62) | 0.0062 | 1.42 (1.11, 1.83) | 0.0057 | |
| Tertile 3 | 1.79 (1.50, 2.14) | <0.0001 | 1.48 (1.22, 1.79) | <0.0001 | 1.80 (1.41, 2.28) | <0.0001 | |
| P for trend | <0.0001 | <0.0001 | <0.0001 | ||||
| SIRI | Continuous variable | 1.21 (1.16, 1.27) | <0.0001 | 1.02 (0.97, 1.08) | 0.4300 | 1.06 (0.99, 1.13) | 0.1074 |
| Tertile 1 | Reference | Reference | Reference | ||||
| Tertile 2 | 1.25 (1.03, 1.53) | 0.0251 | 1.05 (0.85, 1.30) | 0.6571 | 1.18 (0.91, 1.53) | 0.2152 | |
| Tertile 3 | 2.11 (1.77, 2.53) | <0.0001 | 1.12 (0.91, 1.37) | 0.2760 | 1.22 (0.95, 1.57) | 0.1227 | |
| P for trend | <0.0001 | 0.2575 | 0.1818 | ||||
| AISI | Continuous variable | 1.00 (1.00, 1.01) | <0.0001 | 1.00 (1.00, 1.01) | <0.0001 | 1.00 (1.00, 1.01) | 0.0202 |
| Tertile 1 | Reference | Reference | Reference | ||||
| Tertile 2 | 1.28 (1.06, 1.54) | 0.0094 | 1.24 (1.01, 1.51) | 0.0380 | 1.44 (1.13, 1.85) | 0.0034 | |
| Tertile 3 | 1.65 (1.38, 1.97) | <0.0001 | 1.21 (0.99, 1.47) | 0.0575 | 1.38 (1.08, 1.76) | 0.0089 | |
| P for trend | <0.0001 | 0.1401 | 0.0453 | ||||
In sensitivity analysis, MLR, NLR, PLR, SII, SIRI, and AISI, were converted from continuous variables to categorical variables (tertiles).
a
OR: odd ratio.
b
95% CI: 95% confidence interval.
c
Model 1: No covariates were adjusted.
d
Model 2: Adjusted for age, education level, and race.
e
Model 3: Adjusted for age, race, education level, serum uric acid, serum total calcium, TC, triglycerides, total bilirubin; BMI, eosinophil percentage, basophils percentage, smoking status, alcohol consumption, AST, ALT, PIR, diabetes, and hypertension.