TABLE 3.
Threshold effect analysis of MLR and other inflammatory markers on PCa using a two-piecewise linear regression model in Model 3.
| MLR | NLR | PLR | SII | SIRI | AISI | |
|---|---|---|---|---|---|---|
| Standard linear model | ||||||
| OR a (95%CI b ) | 2.28 (1.44, 3.62) | 1.10 (1.04, 1.16) | 1.00 (1.00, 1.01) | 1.00 (1.00, 1.01) | 1.06 (0.99, 1.13) | 1.00 (1.00, 1.01) |
| p-value | 0.0005 | 0.0004 | <0.0001 | 0.0013 | 0.1074 | 0.0202 |
| Fitting by two-piecewise linear model | ||||||
| Breakpoint (K) | 0.5 | 4.32 | 215 | 822.68 | 1.36 | 257.6 |
| OR1 (<K) | 4.77 (1.89, 12.02) | 1.20 (1.09, 1.32) | 1.01 (1.00, 1.01) | 1.00 (1.00, 1.01) | 1.48 (1.06, 2.07) | 1.00 (1.00, 1.01) |
| 0.0009 | 0.0002 | <0.0001 | <0.0001 | 0.0199 | 0.0073 | |
| OR2 (>K) | 1.38 (0.65, 2.92) | 1.02 (0.92, 1.12) | 1.00 (0.99, 1.00) | 1.00 (0.99, 1.00) | 1.01 (0.93, 1.11) | 1.00 (0.99, 1.00) |
| 0.3972 | 0.7072 | 0.2014 | 0.8444 | 0.7499 | 0.2863 | |
| OR2/OR1 | 0.29 (0.07, 1.12) | 0.85 (0.72, 0.99) | 0.98 (0.98, 0.99) | 0.99 (0.98, 0.99) | 0.68 (0.47, 0.99) | 1.00 (1.00, 1.01) |
| 0.0734 | 0.0383 | 0.0267 | 0.0008 | 0.0419 | 0.0134 | |
| Logarithmic likelihood ratio test p-value | 0.069 | 0.032 | 0.024 | <0.001 | 0.039 | 0.011 |
Adjusted for age, race, education level, serum uric acid, serum total calcium, TC, triglycerides, total bilirubin; BMI, eosinophil percentage, basophils percentage, smoking status, alcohol consumption, AST, ALT, PIR, diabetes, and hypertension.
a
OR: odd ratio.
b
95% CI: 95% confidence interval.