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. 2024 Feb 9;17(6):923–937. doi: 10.1016/j.jcmgh.2024.01.025

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© 2024 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Transcriptome analysis identifies the functional roles of LOX in esophageal epithelium. (A) Heatmap and (B) volcano plot of DEGs based on RNA sequencing data from GFP or LOX OE EPC2-hTERT organoids. Up-regulated and down-regulated DEGs in LOX OE organoids are shown with red and blue, respectively. Top 5 (C) enriched and (D) depleted terms in LOX OE organoids based on Gene Ontology analysis. (E) Gene Set Enrichment Analysis based on the PID. The top 10 enriched pathways in LOX OE organoids are shown. Dot size and color represent the number of core enrichment genes and normalized enrichment score (NES) for the pathway, respectively. FDR, false discovery rate.