Table 1.

Cysteine PTM of proteins of the NFκB pathway.

	Protein	Cysteine(s)	PTM	Effect on NFκB activity	System	Validation	Reference (s)
1	p50	62	Homodimer disulfide	Increase DNA binding	Recombinant protein	Point mutation (PM) recombinant protein	[134,136]
	p50	62	Glutathionylation	Decrease DNA binding	Recombinant protein	PM in recombinant protein	[137]
	p50	62	S-nitrosylation	Decrease DNA binding	Recombinant protein	PM in recombinant protein	[138]
2	p65	38	S-nitrosylation	Decrease DNA binding	Peritoneal macrophages & RAW264.7	PM in HEK293T	[139,140]
	p65	38	Sulfhydration	Increase DNA binding	Peritoneal macrophages & RAW264.7	PM in RAW264.7	[141]
3	IKKβ	179	Glutathionylation	Inhibit NFκB activity	Alveolar epithelial cells (C10)	PM in C10 cells	[142]
4	NEMO	54 & 347	Intramolecular disulfide bond	Promote NFκB activity	Peritoneal macrophages & BMDMs	PM in peritoneal macrophages and BMDMs	[30]