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. 2024 Apr 5;15:1357285. doi: 10.3389/fphys.2024.1357285

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Copyright © 2024 Bhatti and Sato.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Structure and major domains of the gasdermin family members and Venn diagram of apoptosis, GSDME-pyroptosis, and GSDMD-pyroptosis. (A) Structural domains of gasdermins and cleavage area, Protein structure retrieved from Protein Data Bank (PDB) PDB ID: 6N90 (B) Overlapping and differential components of GSDMD/GSDME-pyroptosis and apoptosis are displayed in a Venn diagram. Apoptosis is marked by member blebbing and cleavage of poly (ADP-ribose) polymerase (PARP) and pyroptosis is marked by inflammatory response, osmotic lysis, and cell swelling. GSDME-mediated pyroptosis is mediated by caspase 3, whereas GSDMD is mediated by caspase 1/4/5/11. Image built with Biorender.