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. 2024 Apr 8;146(15):10621–10631. doi: 10.1021/jacs.4c00253

Figure 2.

Figure 2

Optimization of the TACO chemistry. (a) Development of the TACO reaction for modification of dimethyllysine Kme2 in peptide FKme2V 1a by exploring varying oxidizing reagents. (b) Evaluation of bases and optimization to the peptide aldehyde FKme2(CHO)V 2a. Reaction conditions: To 6–10 mM of dimethyllysine peptide in 300 μL of 10 mM sodium phosphate buffer (NaP, pH 7.0) were added a base (5 equiv) and oxidizing reagent (2 equiv), and the reaction mixture was stirred for 1 h at room temperature.