Table 3. Main probiotics used in the treatment of childhood diarrhea.
| Probiotic or formula | Dose | Age group | Type of diarrhea | Findings |
|---|---|---|---|---|
| B. lactis | 14.5×106CFU/100 mL milk for 7 days | Less than 2 years | Essentially viral | Reduction of the duration of diarrhea (24 h) and the length of hospitalization (48 h) |
| B. longum, B. lactis, L. acidophilus, L. rhaminosus, L. plantarum, and P. pentosaceus | 109 CFU | 3 months-7 years | Viral (Rotavirus) | Reduction of the duration of diarrhea (2 days) and vomiting (1 day) |
| E. coli Nissle | 108 CFU | 1 month-4 years | Bacterial and viral | Effective in the treatment of diarrhea lasting more than 4 days |
| L. rhamnosus GG | 109 CFU | 3 months-3 years | Bacterial and viral | Diarrhea and associated symptoms |
| 1010 CFU/250 mL of ORS2 | 1 month-3 years | Viral (Rotavirus) | Reduction in the duration of diarrhea | |
| 109 CFU | 6 months-5 years | Viral (Rotavirus) | Reduction in the duration of diarrhea (18 h) and improvement of stool consistency. | |
| LGG, S. boulardii, B. claudii; L. delbrueckii var bulgaricus, S. thermophilus, L. acidophilus, B. bifidum, and E. faecium SF68. | 107-10th CFU | 3 months-3 years | Viral | Reduction in the duration of diarrhea by LGG (37 h) or mixing (45 h) and reduction in the number of bowel movements. |
| L. paracasei ST 11 | 5×109 CFU/2 for 5 days | 4 months-2 years | Bacterial and viral | Reduction of the frequency of bowel movements |
| L.reuteri DSM 17938 | 1×108CFU + ORS for 5 days | 3 months-5 years | Viral | Reduction in the duration of diarrhea (15 h) |
| 108 CFU | 3 months-5 years | Viral | Reduction in the duration of diarrhea (35 h) and length of hospitalization (24 h) | |
| 4×108 | 6 months-3 years | Viral | Reduction in the frequency and duration of diarrhea (1.2 days) | |
| 108 CFU/day | 3 months | Bacterial | Reduction in enteropathogenic colonization | |
| L rhamnosus 19070-2 and L.reuteri C+DSM 12246 | 1010 CFU | 9 months-4 years | Bacterial and viral | Reduction in the duration of diarrhea (40 h) |
| S. boulardii | 250 mg/day | 3 months-7 years | Bacterial, parasitic, and viral | Reduction in the duration of diarrhea (24 h) and length of hospitalization (24 h) |
| 500 mg/day for 5 days | 3 months-5 years | Viral (Rotavirus) | Reduction in duration of diarrhea (29 h) and length of hospital stay (17 h) | |
| 250 mg/1 or 2 days (depending on age) | 3 months-2 years | Viral | Reduction in the duration of diarrhea (1.5 days) and frequency of bowel movements | |
| S. boulardii + metronidazole | 250 mg/2×daily for 7 days | 10-12 years | Parasitic | Reduction in the duration of the time of elimination of blood in the stool |
CFU: colony forming units. From do Carmo et al. 2018 (45; Food Funct 2018; 9: 5074-5095, doi: 10.1039/c8fo00376a).