Table 1.
Baseline demographic and clinical characteristics in men
| All (N=897) | Tertile 1 (N=306) | Tertile 2 (N=299) | Tertile 3 (N=292) | |
|---|---|---|---|---|
| Uric acid (mg/dL) | 6.6 (5.4-7.9) | <5.9 | 5.9-7.4 | >7.4 |
| Age, years | 70 (61-78) | 70 (60-78) | 68 (60-77) | 70 (61-78) |
| Body mass index, kg/m2 | 29.6 (25.9-34.0) | 28.1 (24.2-32.3) | 30.4 (26.4-34.7) † | 30.5 (26.4-35.1) † |
| Systolic BP, mmHg | 128 (115-142) | 128 (116-142) | 128 (115-142) | 126 (113-144) |
| Diastolic BP, mmHg | 68 (58-78) | 69 (58-77) | 70 (60-78) | 66 (58-77) |
| Heart rate, bpm | 70 (62-78) | 70 (60-76) | 70 (60-78) | 69 (62-78) |
| Race, n (%) | ||||
| Non-Hispanic White | 522 (58.2) | 173 (56.5) | 178 (59.5) | 171 (58.6) |
| No-Hispanic Black | 179 (20.0) | 54 (17.6) | 47 (15.7) | 78 (26.7) †‡ |
| Mexican American | 93 (10.4) | 37 (12.1) | 38 (12.7) | 18 (6.2) †‡ |
| Other | 103 (11.4) | 42 (13.8) | 36 (12.1) | 25 (8.5) † |
| History of smoking, n (%) | 643 (71.7) | 215 (70.3) | 218 (72.9) | 210 (71.9) |
| History of drinking, n (%) | 691 (77.0) | 227 (74.2) | 241 (80.6) | 223 (76.4) |
| Hypertension, n (%) | 721 (80.4) | 231 (75.5) | 241 (80.6) | 249 (85.3) † |
| Diabetes mellitus, n (%) | 387 (43.1) | 134 (43.8) | 123 (41.1) | 130 (44.5) |
| Coronary heart disease, n (%) | 432 (48.2) | 148 (48.4) | 153 (51.2) | 131 (44.9) |
| Stroke, n (%) | 184 (20.5) | 72 (23.5) | 54 (18.1) | 58 (19.9) |
| Laboratory tests | ||||
| WBC, 103/uL | 7.3 (6.1-8.8) | 7.3 (6.0-8.5) | 7.3 (6.0-8.8) | 7.3 (6.1-8.9) |
| Hemoglobin, g/dL | 14.0 (12.5-15.0) | 14.1 (12.6-15.1) | 14.1 (12.8-15.0) | 13.7 (12.1-14.9) ‡ |
| Albumin, g/L | 41.0 (39.0-43.0) | 41.0 (38.0-44.0) | 41.0 (39.0-43.0) | 41.0 (39.0-43.0) |
| HbA1c, % | 5.9 (5.5-6.6) | 5.9 (5.4-6.7) | 5.9 (5.5-6.5) | 6.0 (5.5-6.6) |
| Total cholesterol, mmol/L | 4.3 (3.6-5.1) | 4.3 (3.6-5.0) | 4.4 (3.6-5.2) | 4.4 (3.6-5.3) |
| Triglycerides, mg/dL | 135.0 (91.5-200.5) | 128.0 (84.0-192.5) | 143.0 (97.0-202.0) | 139.0 (95.0-205.8) |
| Serum glucose, mg/dL | 102.0 (92.0-128.0) | 102.0 (91.0-135.0) | 100.0 (91.0-124.0) | 104.0 (93.0-125.0) |
| eGFR, mL/min/1.73m2 | 67.5 (50.2-88.2) | 76.8 (59.3-94.7) | 69.5 (53.3-88.8) † | 55.8 (40.4-71.2) †‡ |
| Serum sodium, mmol/L | 139.0 (138.0-141.0) | 139.0 (137.0-141.0) | 139.0 (138.0-141.0) | 139.0 (138.0-141.0) |
| Serum potassium, mmol/L | 4.2 (3.9-4.5) | 4.2 (4.0-4.5) | 4.1 (3.9-4.4) † | 4.2 (3.9-4.5) ‡ |
| Serum chloride, mmol/L | 103.0 (100.0-105.0) | 103.0 (100.0-105.0) | 103.0 (101.0-105.0) | 102.0 (100.0-105.0) |
| Medication | ||||
| ACEI/ARB, n (%) | 504 (56.2) | 145 (47.4) | 167 (55.9) † | 192 (65.8) †‡ |
| Beta blockers, n (%) | 534 (59.5) | 169 (55.2) | 171 (57.2) | 194 (66.4) †‡ |
| MRA, n (%) | 64 (7.1) | 9 (2.9) | 19 (6.4) † | 36 (12.3) †‡ |
| Diuretics, n (%) | 431 (48.0) | 89 (29.1) | 135 (45.2) † | 207 (70.9) †‡ |
| Urate-lowering agents, n (%) | 78 (8.7) | 37 (12.1) | 27 (9.0) | 14 (4.8) †‡ |
Values are presented as median (interquartile range), or n (%). For P-value, † indicates p value < 0.05 versus Tertile 1, ‡ indicates p value < 0.05 versus Tertile 2
Abbreviations: ACE-I, angiotensin-converting inhibitor; ARB, angiotensin II receptor blocker; BP, blood pressure; eGFR, the rate of estimated glomerular filtration rate; Hb1Ac, hemoglobin A1c; MRA, mineralocorticoid-receptor antagonist; WBC, white blood cells