Table 4.
Association of SUA and all-cause mortality via Cox regression analysis
| Unadjusted model | Adjusted model | |||
|---|---|---|---|---|
| HR (95% CI) | p value | HR (95% CI) | p value | |
| Whole population (N=1593) | ||||
| Continuous per 1 unit increase | 1.15 (1.11-1.19) | <0.001 | 1.09 (1.05-1.14) | <0.001 |
| Tertile 1 (<5.5 mg/dL) | Reference | -- | Reference | -- |
| Tertile 2 (5.6-7.0 mg/dL) | 0.96 (0.81-1.14) | 0.657 | 0.94 (0.78-1.12) | 0.474 |
| Tertile 3 (>7.0 mg/dL) | 1.52 (1.29-1.78) | <0.001 | 1.28 (1.06-1.54) | 0.009 |
| Men (N=897, 56.3%) | ||||
| Continuous per 1 unit increase | 1.14 (1.09-1.20) | <0.001 | 1.11 (1.05-1.18) | <0.001 |
| Tertile 1 (<5.9 mg/dL) | Reference | -- | Reference | -- |
| Tertile 2 (5.9-7.4 mg/dL) | 0.99 (0.79-1.24) | 0.914 | 1.05 (0.82-1.33) | 0.720 |
| Tertile 3 (>7.4 mg/dL) | 1.71 (1.38-2.12) | <0.001 | 1.49 (1.17-1.91) | 0.001 |
| Women (N=696, 43.7%) | ||||
| Continuous per 1 unit increase | 1.16 (1.10-1.23) | <0.001 | 1.05 (0.98-1.12) | 0.186 |
| Tertile 1 (<5.1 mg/dL) | Reference | -- | Reference | -- |
| Tertile 2 (5.1-6.5 mg/dL) | 1.28 (0.99-1.67) | 0.064 | 0.97 (0.73-1.28) | 0.834 |
| Tertile 3 (>6.5 mg/dL) | 1.64 (1.27-2.12) | <0.001 | 1.03 (0.77-1.39) | 0.836 |
The multivariate Cox regression analysis was adjusted for age, race, diabetes, stroke, drinking history, BMI, diastolic BP, WBC, hemoglobin, albumin, total cholesterol, eGFR, serum potassium, serum sodium, serum chloride, prescription of beta-blockers, prescription of MRA, prescription of diuretics, and prescription of urate-lowering agents
Abbreviation: BMI, body mass index; BP, blood pressure, eGFR, the rate of estimated glomerular filtration rate; WBC, white blood cell; MRA, mineralocorticoid-receptor antagonist; HR, hazard ratio; CI, confidence interval