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Patient survival in relation to TMB, PD-L1, or microsatellite status and genetic alterations. Kaplan-Meier plots of median (A) PFS and (B) OS of TMB high versus TMB low patients. Median (C) PFS and (D) OS of PD-L1 positive versus PD-L1 negative patients. Median (E) PFS and (F) OS of MSI versus MSS patients. MSI, microsatellite instability; MSS, microsatellite stability; PD-L1, programmed death-ligand 1; TMB, tumor mutational burden
