Fig. 5.

Anlotinib enhances the anti-tumor activity of PD-1 blockade. a Timeline of the animal experiments; blue arrows indicate injections of αPD-1. b (left) Photographs of tumors from each group; (right) tumor growth curves in the mice. (c)The tumor weights and volumes. Results are the means ± SEM, n = 5. A two-tailed unpaired Student’s t test was used for comparisons. For tumor growth curves, statistical analysis was performed using two-way ANOVA with Sidak correction for multiple comparisons. *p < 0.05, **p < 0.01