Table 3.
Univariate and multivariate Cox proportional hazard regression analyses of 18 biomarkers
| Gene | Univariate | Multivariate (18 markers) | ||
|---|---|---|---|---|
| HR (95% CI) | p value | HR (95% CI) | p value | |
| ARNTL2 | 1.35(1.19–1.53) | 4.45E−06 | 1.01(0.83–1.24) | 0.89 |
| PLA2G4F | 0.83(0.77–0.90) | 7.82E−06 | 0.94(0.84–1.04) | 0.24 |
| CYP17A1 | 0.91(0.86–0.95) | 5.49E−05 | 0.94(0.89–1.00) | 3.54E−02 |
| LOXL2 | 1.31(1.15–1.51) | 8.39E−05 | 1.13(0.94–1.35) | 0.20 |
| HMMR | 1.32(1.14–1.53) | 2.13E−04 | 1.03(0.83–1.28) | 0.80 |
| NKX2-5 | 1.09(1.04–1.15) | 3.23E−04 | 1.04(0.98–1.10) | 0.21 |
| GJB2 | 1.20(1.08–1.32) | 3.86E−04 | 1.02(0.90–1.17) | 0.73 |
| DSG3 | 1.10(1.04–1.16) | 4.09E−04 | 1.00(0.95–1.07) | 0.88 |
| SIX1 | 0.84(0.77–0.93) | 4.24E−04 | 0.86(0.76–0.98) | 2.38E−02 |
| MC4R | 0.91(0.86–0.96) | 8.00E−04 | 0.95(0.89–1.00) | 6.65E−02 |
| TRPA1 | 1.13(1.05–1.21) | 9.70E−04 | 1.00(0.91–1.10) | 0.94 |
| RAET1L | 1.07(1.03–1.12) | 1.12E−03 | 1.00(0.95–1.06) | 0.87 |
| KLF4 | 1.28(1.10–1.49) | 1.47E−03 | 1.15(0.96–1.39) | 0.13 |
| HSF2BP | 1.30(1.11–1.53) | 1.48E−03 | 1.04(0.88–1.25) | 0.63 |
| GRIP1 | 1.21(1.08–1.37) | 1.69E−03 | 1.19(1.05–1.35) | 8.53E−03 |
| PTPRN | 1.10(1.03–1.16) | 1.69E−03 | 1.02(0.94–1.09) | 0.66 |
| MAPK4 | 1.10(1.04–1.17) | 2.01E−03 | 1.05(0.99–1.12) | 0.11 |
| PLOD2 | 1.23(1.08–1.40) | 2.14E−03 | 1.06(0.87–1.29) | 0.57 |